Brown adipose tissue is activated by the cold to release anti-inflammatory compounds. Over 40% of adult Americans are obese, a complicated condition that raises the risk of diabetes, heart disease, and several types of cancer. By creating low-grade chronic inflammation and the buildup of immune cel
Researchers found that by lowering inflammation, cold temperatures can help in the fight against obesity and related metabolic diseases.Over 40% of adult Americans are obese, a complicated condition that raises the risk of diabetes, heart disease, and several types of cancer. By creating low-grade chronic inflammation and the buildup of immune cells in insulin-sensitive tissues, obesity is one factor that can contribute to other health issues.
In the current study, the researchers created a mouse model that, when given a standard high-fat, Western diet, develops obesity. “We found that brown fat produces Maresin 2, which resolves inflammation systemically and in the liver,” said co-corresponding author Matthew Spite, Ph.D., a lead investigator at Brigham and Women’s Hospital and Associate Professor of Anesthesia at Harvard Medical School. “These findings suggest a previously unrecognized function of brown adipose tissue in promoting the resolution of inflammation in obesity via the production of this important lipid mediator.
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