Chronic pruritus of unknown origin becomes more common as people get older and is sometimes debilitating, according to Shawn Kwatra, MD.
WASHINGTON — Immunoglobulin E and eosinophils appeared to be reliable biomarkers of type 2 inflammation in chronic pruritus of unknown origin and predictors of a positive response to immunomodulatory therapies, Shawn Kwatra, MD, said at the ElderDerm conference on dermatology in older patients hosted by the GW School of Medicine & Health Sciences.
In one of several cases shared by Kwatra and Manjunath, a 71-year-old Black woman with a 6-month history of generalized itch and a history of type 2 diabetes, hypertension, and chronic kidney disease was found to have elevated eosinophil levels and a negative malignancy workup. Previous therapies included antihistamines and topical steroids. She was started on a 600-mg loading dose of subcutaneous dupilumab followed by 300 mg every 14 days. At the 2-month follow-up, her WI-NRS score was 0.
One of these patients was a 73-year-old White man who had experienced total body itch for 1.5 years and a history of ascending aortic aneurysm, hypertension, and hyperlipidemia. Previous failed therapies included dupilumab , topical steroids, tacrolimus, and antihistamines. Labs showed elevated IgE and eosinophil levels . After 12 weeks of treatment with abrocitinib, the WI-NRS decreased to 2.
Pruritus Pruritis Itch Biologic Therapy Biologics Ige Immunoglobulin E Eosinophils Eosinophil Granulocytes Thyroid Disorder Thyroid Disease Thyroid Dysfunction Hepatocellular Carcinoma HCC - Hepatocellular Carcinoma Liver Cancer HCC Hepatocellular Cancer Cancer Of The Liver Liver Carcinoma Carcinoma Of The Liver COVID-19 2019 Novel Coronavirus 2019-Ncov
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