The research on atopic dermatitis demonstrates that 'the age of onset is distributed well throughout the lifespan,' said Jonathan Silverberg, MD, PhD, MPH.
WASHINGTON, DC — The onset of atopic dermatitis in older adulthood — even in adults aged ≥ 90 years — is a phenomenon documented in the literature in recent years, with reports showing age-related immune differences and differences in risk factors,, MD, PhD, MPH, said at the ElderDerm Conference on dermatology in the older patient hosted by the George Washington University School of Medicine and Health Sciences, Washington, DC.
"The peak usage for dermatologists, primary care physicians, etc., is happening in the first few years of life, partially because that's when the disease is more common and more severe but also partially because that's when parents and caregivers are first learning the disease and trying to understand how to gain control," Silverberg said at the meeting, presenting data from an expanded, unpublished analysis of NAMCS data showing these same outpatient utilization patterns.
Adults aged > 60 years showed more lesions on the trunk and extensor sites of the extremities and lower levels of serum IgE and peripheral eosinophil counts than those in younger age groups. And"interestingly," compared with healthy controls, older patients with AD had"higher levels of serum expression of a variety of cytokines, including IL -4 but also high TARC levels…and a variety of cytokines related to the Th17, TH1 axes, etc.," he said.
"The aging population has dysregulated sleep patterns and altered circadian rhythms, so some of this is just natural predisposition," Silverberg said."But it's amplified , and it becomes a big clinical problem when we get into treatment because it's our natural inclination to prescribe antihistamines for their sedative properties."
Geriatrics Elder Care Geriatric Medicine Older Adults Seniors Senior Citizens Elderly Toxicology Toxicity Poisoning Toxins Elderly/Concerns Of Older Adults Elderly Atopic Dermatitis Atopic Eczema Children Child Childhood Pediatrics Kids Genomics Genomic Medicine Genetics Environmental Exposure Pollutant Pollution Sleep Asthma Asthmatic Ige Immunoglobulin E
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