Cilta-cel is the first CAR T-cell therapy to show a significant OS benefit in multiple myeloma.
"Cilta-cel is the first CAR T -cell therapy to demonstrate an overall survival benefit in multiple myeloma ," María-Victoria Mateos, MD, PhD, said during a presentation of the
At the latest analysis, PFS was not reached in the cilta-cel arm and was 11.79 months with SoC, Mateo said. Median duration of response was not reached with cilta-cel and was 18.69 months with SoC, and median time to symptom worsening was not reached vs 34.33 months, respectively.The CARTITUDE findings continue to support the overall benefit-risk profile of cilta-cel vs SoC in patients with lenalidomide-refractory multiple myeloma as early as after the first relapse, Mateo concluded.
"We do not know if overall survival benefit would have been present if the control arm was better and if there was access to better post-protocol therapy.""I think of it as high risk-high reward. There was a sevenfold increased incidence of secondary hematological malignancies in the cilta-cel arm compared to standard of care — this is a very concerning signal that dampens my enthusiasm to use this drug early for everyone," he added.
Myeloma Plasma Cell Myeloma Chimeric Antigen Receptor T-Cell Therapy Chimeric Antigen Receptors Chimeric Immunoreceptors Chimeric T-Cell Receptors Artificial T-Cell Receptors CAR T Chimaeric Antigen Receptor T-Cell Therapy Chimaeric Antigen Receptors Chimaeric Immunoreceptors Chimaeric T-Cell Receptors Biologic Therapy Biologics Transplantation Of Stem Cells
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Pixel phones getting Android 15 update after U.S. holiday, last update for Pixel 6Abdullah is an ardent believer in the future of VR, and can't wait to see what more it brings to the table as technology improves. He enjoys covering new software releases in the XR industry, as well as major news about hardware and companies focused on VR.
Read more »
UPDATE: Seattle Mariners Provide Injury Update on Luis Castillo After M's WinThe Seattle Mariners were leading, 7-2, on Sunday but lost Luis Castillo to injury in the fourth inning.
Read more »
New GRRM Adaptation Starring Dave Bautista & Milla Jovovich Gets First Look & US Release UpdateDave Bautista in Dune next to Milla Jovovich
Read more »
The Fantastic Four: First Steps’ Unexpected 2024 Update Might Be My Favorite Reveal About It YetThe Fantastic Four in blue costumes in MCU poster
Read more »
Dior’s Highest-End Skin Care Line Just Got Its First Update in 17 YearsDior's L'Or de Vie, its highest-end skin care line, just got an update to its formula for the first time since 2007. Here's what's inside.
Read more »
'Euphoria' Season 3 Gets Its First Positive Update in a Long TimeDenis is a professional writer covering entertainment topics focusing on TV shows. He writes reviews and news for all genres.
Read more »