A retrospective study analyzing data from over 4,000 CYAC survivors in the UK found that treatments like total body irradiation and allogeneic HSCT significantly increase the risk of developing diabetes later in life. The study highlights the need for lifelong monitoring and risk-stratified screening for diabetes in CYAC survivors.
Treatments for childhood and young adult cancer , especially total body irradiation and allogeneic hematopoietic stem cell transplantation , are associated with an increase in the long-term risk of developing diabetes among survivors. Although CYAC survivors are at higher risk of developing diabetes than the general population, which specific cancer treatments might be more likely to increase this risk remains unclear.
The primary outcome was incident diagnosis of diabetes, identified through inpatient hospital clinical coding and A1c values. Corticosteroid treatment increased the standardized CIFs for diabetes from 3.1% at 10 years to 16.3% at 40 years after diagnosis. The difference in standardized CIFs between those treated with corticosteroids and those who were not increased from 1.6% at 10 years to 7.7% at 40 years.
CYAC CANCER DIABETES TREATMENT RISK
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