Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice. The novel drug CT-179 was shown to target a specific subset of tumor cells responsible for recurrence and therapy resistance in pediatric brain cancer. The findings could lead to more effective, less toxic treatments, improving survival and quality of life for young patients.
Breakthrough in childhood brain cancer research could heal treatment-resistant tumors, keep them in remission
The lead researchers have acknowledged the findings as potentially transformative for the treatment of the most common childhood brain cancer, medulloblastoma, and could apply to other brain cancers such as glioblastoma and diffuse intrinsic pontine glioma . The research teams collaborated with U.S. drug company, Curtana Pharmaceuticals, that developed the experimental small molecule drug, termed CT-179. They found that the drug effectively targets the protein OLIG2, which is a known stem cell marker crucial in the initiation and recurrence of brain cancers.
In the study, the researchers focused on medulloblastomas, a common childhood brain tumor. Through advanced tools like CRISPR gene editing, single-cell RNA sequencing, and collaborative drug testing, the study identified the OLIG2 protein as a key regulator of the tumor's growth transitions. The findings present a novel therapeutic angle, highlighting a shift from general tumor treatment to precise interventions targeting tumor-initiating cells.
CHILDHOOD BRAIN CANCER TREATMENT THERAPEUTIC TARGET TUMOR CELLS REMISSION
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