Researchers at Oxford University and the University of Birmingham have made a major breakthrough in cancer treatment by creating the first human bone marrow 'organoids' that accurately replicate the key features of human bone marrow. The technology, which is the subject of a patent application filed
have made a major breakthrough in cancer treatment by creating the first human bone marrow “organoids” that accurately replicate the key features of human bone marrow. The technology, which is the subject of a patent application filed by theEnterprise, enables the simultaneous screening of multiple anti-cancer drugs and the testing of personalized treatments for individual cancer patients., closely mimic the cellular, molecular, and architectural features of myelopoietic bone marrow.
Dr. Abdullah Khan, a Sir Henry Wellcome Fellow at the University of Birmingham’s Institute of Cardiovascular Sciences and the first author of the study, said: “Remarkably, we found that the cells in their bone marrow organoids resemble real bone marrow cells not just in terms of their activity and function, but also in their architectural relationships – the cell types ‘self-organize’ and arrange themselves within the organoids just like they do in human bone marrow in the body.
Senior study author Professor Bethan Psaila, a hematology medical doctor as well as a Research Group Leader at the Radcliffe Department of Medicine,, said “To properly understand how and why blood cancers develop, we need to use experimental systems that closely resemble how real human bone marrow works, which we haven’t really had before.
“Having developed and validated the model is the first crucial step, and in our ongoing collaborative work we will be working with others to better understand how the bone marrow works in healthy people, and what goes wrong when they have blood diseases.”
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