Build a registry of results that students can replicate, says Yusuf A. Hannun, director of the Stony Brook University Cancer Center in New York
As the year comes to a close, it’s natural to consider how to improve in future. One step would be to explicitly restructure scientific publications to fulfil their functions as building blocks of knowledge. Past suggestions include requiring authors to include statements of generalizability or a numerical confidence level. Here I propose two new strategies.First, every published study should articulate specific testable conclusions.
The main goal is for authors to articulate and ‘own’ explicit testable statements by expressing extremely high confidence in them. That should, in turn, prompt them to clearly articulate the experimental conditions required, for instance by stating whether results were obtained in one cell line or several cancer cell lines. That will also clarify how work might be extended .
A registry of claims for replication would bring multiple benefits. First, requirements to specify which components of an experiment will be replicable would reduce temptations to overstate and overgeneralize results. And it might head off some of the bickering that occurs when one set of researchers says it cannot reproduce another’s ‘work’. Second, researchers might be encouraged to describe their experiments more completely if others are more likely to attempt to formally replicate the work.
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