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A unique genetic mutation in two siblings – that has never been seen in anyone else – has been discovered by UK researchers at the University of Exeter, pointing the way towards new treatment options for"We searched the globe, looking at all the large-scale datasets that we know of, and we haven't been able to find another family,""These siblings therefore provide us with a unique and incredibly important opportunity to investigate what happens when this gene is disabled in...
As PD-L1 and its PD-1 receptor combine as a sort of safety mechanism to keep the immune system in check, andHowever, in a surprising twist, it turned out that the immune systems of the two young siblings were operating pretty much as normal, even without the immune system regulation that PD-L1 and PD-1 normally provide.
"We think that PD-L2, another ligand of PD-1, albeit less well-studied than PD-L1, may be serving as a backup system when PD-L1 is not available,"of tackling the onset of type 1 diabetes – if researchers can figure out how PD-L1 prevents it, and how PD-L2 acts as a backup."This finding increases our knowledge of how autoimmune forms of diabetes such as type 1 diabetes develop. It opens up a new potential target for treatments that could prevent diabetes in the future.
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