New findings suggest that the blood vessels supplying aggressive brain tumors contain receptors that can be targeted by a novel type of drug-delivery nanoparticle. These particles can effectively cut off the tumor's energy supply, hinder its growth and spread, and also cause other disruptions to its
have uncovered high levels of Low-Density Lipoprotein receptors on the blood vessels supplying high-grade glioma brain tumors. This discovery opens up the possibility of utilizing drugs that are already being developed at both institutions to target these receptors, thereby allowing the drugs to be taken up by the tumors.Gliomas are the most common primary brain tumors and originate from the glial cells of the brain.
In its original anti-parasitic application, niclosamide has been used for over 60 years, taken as oral tablets, killing tapeworms on contact in the gut by inhibiting their crucial metabolic pathway and shutting down their energy supply. This same ability to lower the energy supply in a cell, has shown that niclosamide can also reduce the energy aneeds to replicate .
Professor Needham and the team at Duke have developed the “Bricks to Rocks Technology” that makes this common low solubility drug into even less soluble “rocks” for the expressed purpose of making pure prodrug nanoparticles. They converted niclosamide into a new less soluble prodrug that allows the formation of the injectable or implantable nanoparticles.
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