Scientists from the University of Virginia (UVA) have identified a promising approach to delay aging by detoxifying the body of glycerol and glyceraldehyde, harmful by-products of fat that naturally accumulate over time. The new findings come from UVA researcher Eyleen Jorgelina O’Rourke, PhD, an
esponse.” In short, the scientists found that they could prompt an anti-aging response by putting the spurs to a particular gene,. Doing so prompted the gene to produce more of an enzyme, alcohol dehydrogenase, that prevented the toxicity caused by glycerol and, indirectly, glyceraldehyde. The result was that the worms lived longer, healthier lives.
University of Virginia researcher Eyleen Jorgelina O’Rourke, PhD, and her team found that they could improve health and extend lifespan by targeting two harmful fat by-products, glycerol and glyceraldehyde. Credit: Dan Addison | UVA Communications “We hope to attract interest in developing therapeutics that target AMAR,” said O’Rourke, who is part of UVA’s Robert M. Berne Cardiovascular Research Center. “With age-related diseases currently being the major health burden for patients, their families and the healthcare system, targeting the process of aging itself would be most effective way to reduce this burden and increase the number of years of independent healthy living for all of us.
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