A new study finds that brain cells with the same “birthdate” are more likely to wire together into cooperative signaling circuits that carry out many functions, including the storage of memories. “Our study’s results suggest that which day a hippocampal neuron is born strongly influences both how
. With changes to the number of cells born on different days, the developing brain may be more vulnerable on some gestational days to viral infections, alcohol, or toxins.
“Our study’s results suggest that which day a hippocampal neuron is born strongly influences both how that single cell performs, and how populations of such cells signal together throughout life,” says senior study author György Buzsáki, MD, PhD, the Biggs Professor in the Department of Neuroscience and Physiology at NYU Langone Health.
Past work had shown that activity in the hippocampus can be described in terms of patterns of collective neuronal activity during waking and sleep. During sleep, for instance, when each day’s memories are consolidated for long-term memory storage, hippocampal neurons engage in a cyclical burst of activity called the “sharp wave-ripple,” named for the shape it takes when captured graphically by EEG, a technology that records brain activity with electrodes.
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