New research shows that the blood marker profile of people with a history of various mental illnesses suggests their bodies are 'biologically older than their actual age'.
in Paris this week has revealed that the blood marker profile of people with a lifetime history of various mental illnesses, including depression, bipolar disorder, and anxiety disorders, suggests their bodies are "biologically older than their actual age".
They noted that people with mental health disorders "tend to have poorer quality health" and "often people with poor mental health show an increased tendency to develop conditions such as heart disease and diabetes" – "and these conditions tend to worsen with age". For example, a 2019 study found that on average people with mental disorders had shorter life expectancy by around 10 years for men and 7 years for women compared with the general population.
They found that those with a mental illness had a metabolite profile older than would have been expected for their age compared with people without a mental illness. Polygenic scores for mental disorders were positively correlated with metabolomic age. "These findings suggest that individuals with a history of mental disorders, or with higher polygenic scores for mental disorders, were biologically older than their chronological age," they concluded.
For example, compared with non-frail people without mental disorders, the all-cause mortality hazard ratio was 3.65 among individuals with both bipolar disorder and frailty.
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