bDMARD therapy preserved renal function in 75% of patients with AA amyloidosis, but the remaining 25% progressed to ESRD despite receiving bDMARD therapy.
Treatment with biologic disease-modifying antirheumatic drugs , particularly tocilizumab, can suppress inflammation and preserve renal function in a majority of patients with chronic inflammatory disorders who develop serum amyloid alpha amyloidosis.
This monocentric, retrospective analysis assessed the effect of bDMARD therapy on inflammatory biomarker levels and renal outcomes in 83 patients with AA amyloidosis who were followed for a mean period of 4.82 years.Idiopathic AA , wherein the primary disease could not be identified Tocilizumab was the most commonly used bDMARD in patients with cid + AA and idio + AA amyloidosis, and interleukin-1 inhibitors were prescribed to patients with auto + AA amyloidosis because tocilizumab has not been approved yet for FMF or CAPS treatment.
bDMARDs prevented progression to end-stage renal disease in 75% of the patients in the overall cohort, with progression to ESRD being prevented in 60% of patients with cid + AA, 88% of patients with auto + AA, and 81% of patients with idio + AA."The data suggest preferential use of IL -1 inhibitors and tocilizumab for clinical use in the treatment of AA amyloidosis depending on the respective underlying diseases," the authors commented.
AA Inflammatory Amyloidosis Amyloid A Amyloidosis Inflammatory Amyloidosis AA Amyloidosis Inflammatory Bowel Disease IBD - Inflammatory Bowel Disease IBD Autoinflammatory Diseases End Stage Renal Disease ESRD - End Stage Renal Disease ESRD ESKD End-Stage Kidney Disease (ESKD) ESKD - End Stage Kidney Disease Renal Disease Kidney Disease Kidney Disorder Renal Disorder
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