The CGRP atogepant is effective in preventing rebound headache related to medication overuse in patients with chronic migraine, new research suggested.
The oral calcitonin gene-related peptide receptor antagonist atogepant is effective in preventing rebound headache related to medication overuse in patients with chronic migraine , new research suggested.
Acute medication overuse is defined as"taking simple analgesics for ≥ 15 days per month or taking triptans, ergots, opioids, or combinations or medications for ≥ 10 days per month." MHDs were also reduced in both treatment groups, with LSMDs of −2.8 and −2.1 , respectively. Mean acute medication use days were lower in both the treatment groups, with LSMDs of −2.8 and −2.6 , respectively.
A limitation cited by the authors was that participants' self-report of migraines and headaches via electronic diaries might have been inaccurate.
Migraine Headache Headache Drug-Induced Headache Rebound Headache Medication Overuse Headache Pain Pain Management Analgesia Analgesic Painkiller Continuing Medical Education CME Data Collection Disability Grant Massachusetts New Jersey Receptors Tryptamines Triptan
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