Use of antihypertensive drugs was associated with a small increase in the rate of eczematous dermatitis diagnoses in older adults, with varying risks with different classes.
Antihypertensive drugs are associated with a small increased risk for eczematous dermatitis in older adults , with the highest association seen for diuretics and calcium channel blockers , in a longitudinal cohort study.Atopic eczema has been increasing among older adults , and drug-induced eczematous dermatitis may be a common reason for a misdiagnosis of atopic eczema in this population.
To evaluate the association of eczematous dermatitis with antihypertensives, researchers analyzed records of 1,561,358 older adults from the THIN cohort, a sample of patients in the United Kingdom, from January 1994 to January 2015.Overall, 105,007 participants were diagnosed with eczematous dermatitis over a median follow-up of 6 years.
The incidence of eczematous dermatitis was higher among adults who received antihypertensive drugs than among those who did not . Any antihypertensive drug use was associated with a 29% higher risk for eczematous dermatitis , after adjusting for potential confounders. Diuretics were associated with the highest risk , followed by calcium channel blockers , angiotensin receptor blockers , and alpha-blockers .
The smallest effects were with angiotensin-converting enzyme inhibitors and beta-blockers ."Based on the currently available evidence, if a clinical workup does not identify another cause for the dermatitis and it is bothersome and does not respond to treatment, clinicians could consider switching treatment to a different class of antihypertensive, such as an ACE inhibitor," the authors wrote.Detailed information on the severity and resolution of dermatitis was not available.
Hypertension Antihypertensive Geriatrics Elder Care Geriatric Medicine Older Adults Seniors Senior Citizens Elderly Eczema Atopic Dermatitis Atopic Eczema Calcium Channel Blockers Arrhythmia Angiotensin-Converting Enzyme Inhibitor Ace Inhibitor Calcium Diuretics
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