Kaletra is one of several existing drugs that are being tested as repurposed coronavirus treatments.
A 'heroic effort' with a 'disappointing' ending, the journal's editor in chief Eric Rubin and deputy editor Lindsey Baden applauded the scientists for running this study under the extraordinary pressure of an epidemic.
"This was a heroic effort," Rubin and Baden wrote."Health care workers in Hubei province have provided patient care in an overwhelming epidemic while they themselves are one of the highest risk groups for development of disease." In answering why Kaletra didn't work, they write that this trial focused on a"particularly challenging patient population" and the HIV drug isn't especially potent against this novel coronavirus.
The patient group had a median age of 58 years old and typically had started to develop symptoms 13 days before first receiving treatment. For both groups, those on Kaletra and those not taking it, it took 16 days on average to see clinical improvement. While the study's main goal was to test to see if Kaletra could speed up the time to clinical improvement, researchers tracked a range of other metrics that may show some benefit.
Patients on Kaletra had a median time in the intensive care unit of 6 days compared to 11 days for the control group. For the slice of patients that were treated within 12 days of developing symptoms, Kaletra did appear to help them get better.
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