Personalized, adaptive deep brain stimulation can offer better control of motor symptoms of Parkinson's disease than standard DBS, a new pilot study showed.
Personalized, adaptive deep brain stimulation can enhance the control of motor symptoms of Parkinson 's disease compared with standard DBS, new research suggests.
"Adaptive DBS represents a major breakthrough in managing the symptom fluctuations in Parkinson's disease by tailoring stimulation in real time to patients' specific needs," Carina Oehrn, MD, PhD, research fellow in the Starr Lab at UCSF, toldDBS is a standard therapy for advanced PD. Standard DBS provides continuous, fixed stimulation that is unresponsive to patient activities or variations in severity of symptoms during daily life.
Using a data-driven approach, they identified brain activity signals in the subthalamic nucleus and motor cortex that were reliable biomarkers of medication fluctuations and associated PD motor symptoms and used it to personalize the DBS parameters. "Once these challenges are addressed, adaptive DBS could become a very promising alternative to standard DBS for PD patients with motor fluctuations," Oehrn said.
Parkinson Disease Parkinsons Parkinson Parkinson Disease (PD) Deep Brain Stimulation DBS - Deep Brain Stimulation Brain Stimulation Brain Adverse Effects Side Effects Fellowship Fellows Grant Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Patient Safety Stroke Cerebrovascular Accident CVA - Cerebrovascular Accident
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