Researchers have developed a model that rapidly converts stem cells to brain cells with protein structures characteristic of Parkinson's disease (PD), enabling the study of the condition's unique and highly variable disease pathology in a petri dish.
Researchers have developed a model that rapidly converts stem cells to brain cells with protein structures characteristic of Parkinson's disease , enabling the study of the condition's unique and highly variable disease pathology in a petri dish.
Existing"Parkinson's in a dish" models can effectively transform stem cells into brain cells, but not within a reasonable timeframe to study patient-specific cellular pathologies to guide tailored treatment strategies. This is important because patients with PD are diverse and a one-size-fits-all treatment strategy may now work for some patients.
While marking progress, the model has several limitations researchers aim to address. For one, it currently generates immature neurons. The researchers aim to replicate this model with mature neurons to model the effects of aging on the protein aggregates that form. While the new system can rapidly create both neurons and key inflammatory"glial" cells in the brain, the current paper only examines these cells individually.
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