University of Southern California and the Cleveland Clinic Florida Research and Innovation Center researchers have published new research on GRP78, a protein implicated in both COVID-19 and numerous forms of cancer, as well as a new drug that interferes with its effects. While vaccination can pro
The new drug may provide a new type of protection against COVID-19, one that will be effective even when new strains emerge.
“A major problem in fighting SARS-CoV-2 is that it is constantly mutating and adapting itself to more efficiently infect and multiply in its host cells,” said Lee, also the Judy and Larry Freeman Chair in basic science research. “If we keep chasing the virus around, this could become quite challenging and unpredictable.
“We now have direct evidence that GRP78 is a proviral protein that is essential for the virus to replicate,” Lee said. “Lo and behold, we found that this drug was very effective in reducing the number and size of SARS-CoV-2 plaques produced in the infected cells, in safe doses which had no harmful effect on normal cells,” Lee said.
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