According to researchers, some people who carry mutations in genes known to cause early onset Alzheimers disease do not show signs of the condition until a very old age — much later than expected.
After his beloved wife was diagnosed with Alzheimer’s, Arthur Kleinman discovered that what he didn’t know was a lotvariant may postpone the clinical onset of Alzheimer’s disease by limiting tau pathology and neurodegeneration.
gene provides instructions for making a protein called apolipoprotein E, which is involved in the metabolism of fats in the body. Experiments revealed that thevariant may reduce the ability of apolipoprotein E to bind to certain sugars called heparan sulphate proteoglycans , which have been implicated in processes involving amyloid beta and tau proteins.
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