A Good Night's Sleep Shows Its Face

Cycles of light and dark regulate not only sleep but skin health.

The suprachiasmatic nuclei in the hypothalamus serve as the central regulator for the circadian rhythm. They respond to light/dark information from melanopsin-expressing retinal ganglion cells and melatonin hormone from the pineal gland. As day turns into night, the human body normally releases melatonin, while the light of day normally inhibits its secretion. The main function of melatonin is to regulate the sleep/wake cycle.

In aging and certain diseases, melatonin production decreases, which leads to circadian disruption. Low levels of melatonin at night may result in poor sleep quality, which is associated with many serious health problems, including cardiovascular disease, obesity, diabetes, and mental disorders. One of the target tissues of melatonin action is the skin.

By restoring circadian rhythmicity, melatonin supplementation can repair skin damage caused by sleep disruption. Melatonin also affectsmechanisms, which lead to the inhibition of some age-related genes and the activation of genes associated with skin health. Therefore, melatonin supplementation can be a promising strategy for preventing age-related skin disorders or disruptions of the circadian cycle induced by environmental factors [5].

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