Scientists have engineered blood clots that form faster and last longer, creating super-clots that could potentially replace existing clot-forming bandages for surgeries and accidents. The artificial clots are made from patient blood, proven to be 13 times more resistant to fracturing and four times more adhesive than natural blood clots.
Scientists have now developed new custom-made blood clots that form faster and last longer than the natural versions. They're called engineered blood clots , or EBCs, and are created via a technique called"click clotting" – via blood from the patient, or The idea is that one day these super-clots – which form in seconds – could be applied as emergency patches for surgeries and accidents.
The team behind the clotting technology, from institutions across Canada and the US, is confident that their EBCs can help plug severe bleeding and support quicker"Natural blood clots can be slow to form and mechanically fragile, which limits their ability to stop severe bleeding and can compromise healing,""Our work shows that, when engineered appropriately, red blood cells can play a central structural role, enabling the design of stronger and more functional biomaterials.
"the volume of clots when they form naturally, but aren't particularly strong in a mechanical sense, which means they can be prone to fracturing. What the researchers did was to turn red blood cells into more sturdy building materials by triggering microscopic chemical reactions to bind them together. These chemical reactions are speedy and safe – and the bioengineered clot can be added to a natural clot in the form of a gel called a cytogel.that provide structural strength.
They're tougher and more substantial, but make up just a small fraction of natural blood clots. The EBCs developed by the researchers, and tested in the lab and in rat models, proved to be 13 times more resistant to fracturing and four times more adhesive than natural blood clots.
According to the team, the super-clot gel can be prepared quickly: in about 10 minutes for its allogeneic form , and in about 20 minutes for its autologous form . , which form inside blood vessels and can block blood flow in the lungs or to the brain. These kinds of clots can be life-threatening, rather than life-saving. , their body's ability to create beneficial blood clots is also reduced.
The cytogel could then make an even bigger difference to blood clot strength and stability. There's still plenty of work to do here. The"click clotting" technique has only been tested in rats so far, and the research team needs to see how these EBCs perform in real-world, clinical situations as well. The EBCs also need to be 'fine-tuned' to change different qualities of the blood clot, to match different scenarios – fromBig breakthroughs. Bold ideas. Straight to your inbox.
Blood Clots Engineered Blood Clots Click Clogging Emergency Patches Severe Bleeding Natural Blood Clots Biomaterials Rapid Clot Formation Algorhythmic Blood Clots Autologous Blood Clots
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