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It's quick and easy to access Live Science Plus, simply enter your email below. We'll send you a confirmation and sign you up for our daily newsletter, keeping you up to date with the latest science news . Reproductive Health Artemis II splashes down, the kākāpō bounces back, the Shroud of Turin gets weirder, and a functional cure for type 1 diabetes Science history: Doctor hypothesizes that 'transmissible proteins' can cause disease, contradicting a 'central dogma' of molecular biology — April 9, 1982 Viruses, Infections & Disease Scientists have discovered an 'Achilles' heel' in deadly superbugs A patient who underwent a HIV-eliminating transplant procedure at age 58 is still in remission from HIV at age 63.
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A 63-year-old man known as the Oslo patient is'likely cured' of HIV after a stem-cell transplant remodeled his entire immune system.. In those cases, the donated cells came from people unrelated to the patients, but in the Oslo patient's case, the transplanted cells came from his brother. His sibling happened to carry a genetic mutation that made him resistant to HIV, doctors reported Monday in the journal The mutation, called CCR5 delta 32, disables a protein on the surface of immune cells that HIV often exploits to trigger infection. The patient's brother carried two copies of this mutation, which effectively locks the virus out of cells that would normally be its prime targets.
'A cure on the horizon': Are we finally close to ending type 1 diabetes? 'A sibling has a 25% probability of being a match for a transplant, and the frequency of CCR5Δ32/Δ32 is around 1%' in northern European populations, study co-author, a hematologist at Oslo University Hospital, where the patient was treated, told Live Science in an email. 'So it is an unlikely scenario, and we were not aware of the donor's CCR5 status before the transplant.'
The Oslo patient had been diagnosed with HIV in 2006, at age 44. In 2010, he started antiretroviral therapy , which suppresses the virus's ability to replicate in the body and thus prevents the infection from progressing to AIDS. The treatment drove the HIV in the man's blood down to undetectable levels, which also However, in 2017, the patient became fatigued, and his blood cell counts plummeted. The next year, he was diagnosed with a type of bone marrow cancer called, in which new blood cells made in the bone marrow fail to mature. Initially, the patient responded well to a drug for the condition and entered remission, but he later relapsed, prompting his doctors to seek a bone marrow transplant instead. Also known as hematopoietic stem cell transplants, bone marrow transplants involve infusing healthy, blood-making stem cells into the body to replace diseased ones. These new stem cells multiply and give rise to new red and white blood cells, ultimately remodeling the patient's blood supply and immune system.
Get the world’s most fascinating discoveries delivered straight to your inbox. Receive email from us on behalf of our trusted partners or sponsors At that point, the patient was referred to Myhre's care at Oslo University Hospital, and the team there searched for a bone marrow donor who happened to carry the coveted CCR5 delta 32 mutation. They were aware of similar cases where patients with HIV and blood cancer had received transplants with the mutation and then entered long-term remission from both their conditions. . Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor.
Nicoletta Lanese is the health channel editor at Live Science and was previously a news editor and staff writer at the site. She holds a graduate certificate in science communication from UC Santa Cruz and degrees in neuroscience and dance from the University of Florida. Her work has appeared in The Scientist, Science News, the Mercury News, Mongabay and Stanford Medicine Magazine, among other outlets. Based in NYC, she also remains heavily involved in dance and performs in local choreographers' work.
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