Changes in vaccine-induced antibody levels in children is associated with demographic variables and influenced by antibiotic exposures.
. We tested 499 infants for antibody levels to multiple routine vaccines given in a 2-4-6 month series. Surprisingly, we found that 11% were what we termed “low responders” because the children developed subprotective antibody levels to at least four of six vaccine antigens that take the vaccine ingredients to the lymph nodes and spleen, where the immune processing occurs.
As expected, the level of antibody following vaccination changed over time for all the children, reflecting the response after completion of the primary vaccines and then antibody decay until boosters were given, resulting in an increase in antibody and then decay again. What was striking to us was that individual children tended to stay in their vaccine response group over time.
Vaccines Children Child Childhood Pediatrics Kids Hepatitis B HBV Hepatitis B Virus (HBV) Hepatitis B Virus Combined Tdap Vaccine Combined Tetanus/Diphtheria/Pertussis Vaccine Tdap Vaccine Tdap Influenza Flu Biologic Therapy Biologics Fellowship Fellows Residency Residents Immunizations Vaccination Antibiotics Antigens Bacteria Bacterial Infection Polio Poliomyelitis
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