A new analysis suggests that chondrocalcinosis is a cause, rather than just a consequence, of knee osteoarthritis.
In an analysis including more than 6400 middle-aged to older adults, individuals with knee chondrocalcinosis were 75% more likely to develop knee OA than those without the condition at baseline. Because knee chondrocalcinosis and OA are often observed together, it is commonly considered a feature of the OA disease process, said Jean W.
Liew, MD, an assistant professor of rheumatology at Boston University, Boston, and coauthor of the study. “This study suggests that calcium crystal deposition is a cause of knee OA rather than just a consequence,” she toldThe analysis included data from two independent cohorts: the Rotterdam Study and the Multicenter Osteoarthritis Study . RS enrolled individuals aged 55 years or older residing in Rotterdam, the Netherlands. MOST, which recruited participants from Birmingham, Alabama, and Iowa City, Iowa, enrolled adults aged 50-79 years with preexisting knee OA or at increased risk for OA due to overweight status, knee injury, or knee symptoms. Researchers examined the association between baseline knee chondrocalcinosis, measured via x-ray, and development of radiographic knee OA over time. Radiographic knee OA was defined as a Kellgren and Lawrence grade ≥ 2 or if the individual had undergone knee replacement at follow-up., included 3737 individuals from the RS cohort and 2750 individuals from the MOST cohort. At baseline in the RS cohort, 76.1% of participants had no signs of radiographic knee OA , and 4.3% had knee chondrocalcinosis. For the MOST cohort, 68.5% had no signs of radiographic knee OA, and 5.0% had knee chondrocalcinosis at baseline. The analysis found that knee chondrocalcinosis increased the risk for incident radiographic knee OA after adjustment for age, sex, and BMI. The pooled odds ratio between both groups was 1.75 . There were no cases of regression of chondrocalcinosis during follow-up, which suggests that chondrocalcinosis does not resolve over time, Liew and colleagues wrote. In a subgroup analysis including only individuals with KLG of 0 at baseline, the results were similar and testing whether treatments that work for crystal-associated arthritis like gout or calcium pyrophosphate deposition disease would also work for knee OA,” she said. “Hints of such benefits have appeared in previous cardiovascular randomized controlled trials of colchicine, where patients receiving the drug had a lower risk of joint replacement as a secondary outcome,” noted Tedeschi. It’s “one interesting therapy to consider” for potential future trials, as are other anti-inflammatory medications like interleukin-1 inhibitors, she added. This research was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Tedeschi has worked as a consultant for Merck, Avalo Therapeutics, and Amgen. Liew reported having no relevant disclosures.Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our
Generalized Osteoarthritis Degenerative Arthritis Generalised Osteoarthritis Osteoarthritis (OA) Degenerative Joint Disease Degenerative Joint Disease (DJD) DJD Chondrocalcinosis Calcium Calcium Pyrophosphate Deposition Disease Knee Osteoarthritis Arthritis Joint Inflammation Iowa Arthroplasty Biologic Therapy Biologics Gout Wound Management Wound Care Alabama
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