A growing number of scientists is trying to help people reach a goal humans have been chasing throughout history: staying active and vital in old age
This microscope photo provided by the Mayo Clinic in August 2022 shows senescent myoblast cells. Senescent cells resist apoptosis, or programmed cell death, and characteristically get big and flat, with enlarged nuclei. They release a blend of molecules, some of which can trigger inflammation and harm other cells — and paradoxically also stimulate the growth of malignant cells and fuel cancer, says Mayo Clinic researcher Nathan LeBrasseur.
With the number of people 65 or older expected to double globally by 2050, cellular senescence is"a very hot topic," says Viviana Perez Montes of the National Institutes of Health. According to an Associated Press analysis of an, there have been around 11,500 total projects involving cellular senescence since 1985, far more in recent years.
“I’m not looking for the fountain of youth,” Wiley says. “I’m looking for the fountain of not being sick when I’m older.”Leonard Hayflick, the scientist who discovered cellular senescence in 1960, is himself vital at 94. He's a professor of anatomy at the University of California, San Francisco, and continues to write, present and speak on the topic.
The finding, Hayflick says, challenged"60-year-old dogma" that normal human cells could replicate forever. A paper he authored with colleague Paul Moorhead was rejected by a prominent scientific journal, and Hayflick faced a decade of ridicule after it was“It followed the usual pattern of major discoveries in science, where the discoverer is first ridiculed and then somebody says, ‘Well, maybe it works’ … then it becomes accepted to some extent, then becomes more widely accepted.
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