Not all surgical incisions are the same.
frameborder="0″ allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen>The range of curvature didn't have a significant effect on speed of healing in wavy wounds, but width needed to be small enough to form bridges.
The experiments showed success with a maximum gap size of 75 micrometers. The team notes this top distance may be different for different cell types, and there could be an effect on bridge formation and healing speed if the curvatures are smaller or larger than the ranges they used. However even in the smallest experimental gap of 30 micrometers, the cells mostly moved parallel to – and rarely towards – the straight cuts. And they didn't form bridges. Hsia and colleagues considered if the bridge formation could have been helped by wavy edges causing more cells to divide and grow, increasing the number of cells available for healing, but calculations ruled this out. "Observations clearly demonstrate that straight and wavy edges provided different geometric confinements to cell migration," theyin their paper,"generating different cell movement patterns …thus different healing efficiency". Another thing the researchers noticed was the position of the cell nucleus. In cells not involved in healing a wound, it was roughly in the middle. Yet in cells over the healed gaps it was clearly off center, seeming to move closer to the cell edges to avoid sitting directly over the gap. This was more noticeable in cells over the wavy wounds. Positions of the nuclei in non wound cells , and in the healed wavy gap region . The nuclei is white and the cells are random colors. (
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