An anti-inflammatory drug for rheumatoid arthritis 'can turn back time in mice and reverse some of the effects of age.'
The Passegué lab decided to thoroughly investigate the bone marrow. The team found that one inflammatory signal released from the damaged bone marrow niche, IL-1B, was "critical in driving aging features, and blocking it with the drug, anakinra, remarkably returned the blood stem cells to aThe researchers will now investigate if the same processes are active in humans and if rejuvenating the stem cell niche earlier in life, in middle age, would be a more "effective strategy.
"Treating elderly patients with anti-inflammatory drugs blocking IL-1B function should help with maintaining healthier blood production," Passegué said, and she hopes the finding will lead to clinical testing.Haematopoietic aging is marked by a loss of regenerative capacity and skewed differentiation from hematopoietic stem cells , leading to impaired blood production.
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