A team aiming to produce the first complex cell with an entirely synthetic genome has created a strain of yeast with half of its chromosomes designed from scratch
A large international team has created a strain of yeast in which half of the 16 chromosomes are synthetic ones that have been redesigned and created from scratch, in a major step towards creating the first complex cell with an entirely synthetic genome.
The team has also added 3000 sites to the genome where they can trigger recombination, where pieces of code are exchanged between different chromosomes. The idea is to There’s also an entirely new 17th chromosome containing all the genes for the tRNAs involved in protein synthesis. Cells need to make lots of tRNAs but because the genes are aligned in different directions on natural chromosomes, enzymes can crash into each other and break the DNA.
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