New research shows adding blinatumomab to chemotherapy improved outcomes in child patients with B-cell acute leukemia.
Among pediatric patients with B- ALL followed for a mean of 2.5 years , 718 patients in the blinatumomab-plus-chemotherapy group had a 3-year DFS of 96.0±1.2% compared with 87.9±2.1% of the 722 patients in the chemotherapy-only group, researchers reported here at the
As Cynthia E. Dunbar, MD, chief of the Translational Stem Cell Biology Branch at the National Heart, Lung, and Blood Institute, noted in a news briefing:"B-cell ALL is the most common childhood cancer and one of the most treatable. However, some children still relapse following standard chemotherapy treatments and then have a much grimmer outcome."
The control group received standard-intensity chemotherapy or augmented Berlin-Frankfurt-Münster -based chemotherapy . In addition, the blinatumomab groups received 2 cycles of the drug.
Acute Leukaemia Children Child Childhood Pediatrics Kids Chemotherapy Leukemia Leukaemia Blood Cancer Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Acute Lymphoblastic Leukemia Acute Lymphocytic Leukemia ALL Acute Lymphoblastic Leukaemia Acute Lymphocytic Leukaemia Childhood Cancer White Blood Cell Count Leukocyte Count WBC Count White Count Blood
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