A new study explains not only why some patients with wet age-related macular degeneration (or 'wet' AMD) fail to have vision improvement with treatment, but also how an experimental drug could be used with existing wet AMD treatments to save vision.
A new study explains not only why some patients with wet age-related macular degeneration fail to have vision improvement with treatment, but also how an experimental drug could be used with existing wet AMD treatments to save vision.
Despite the severe vision loss often experienced by people with wet AMD, less than half of patients treated with monthly eye injections, known as anti-VEGF therapies, show any major vision improvements. Additionally, for those who do benefit with improved vision, most will lose those gains over time.Proceedings of the National Academy of Sciences
The team compared VEGF and ANGPTL4 levels in the eye fluid of 52 patients with wet AMD at various stages of anti-VEGF treatment. Prior to anti-VEGF injections, patients with wet AMD had high levels of ANGPTL4 and VEGF proteins. After treatment, their VEGF levels predictably decreased, yet ANGPTL4 levels rose higher, indicating ANGPTL4 remained active following the anti-VEGF injections and the treatments contributed to an increase in ANGPTL4.
"This work exposes a way to improve anti-VEGF therapy for all patients and potentially help a subset of patients with wet AMD who still lose vision over time despite treatment," Sodhi says."Our hope is that this will further the three goals we have related to wet AMD: make current therapies as effective as possible, identify new therapies, and prevent people from ever getting wet AMD.
Diseases And Conditions Pharmacology Blood Clots Personalized Medicine Hypertension Cosmetic Surgery Today's Healthcare
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Here’s Why AMD Might Not Catch Up to Nvidia's AI Anytime SoonStocks Analysis by MarketBeat.com (Jea Yu) covering: NVIDIA Corporation, Advanced Micro Devices Inc. Read MarketBeat.com (Jea Yu)'s latest article on Investing.com
Read more »
Why Fungi Could Get The Status Of ‘Kingdom’ And Why It MattersDaniela De Lorenzo is a reporter who covers breaking news, features and analysis focusing on sustainable food system policy, agritech and foodtech. She’s covered new policy development in the field of cultivated meat. Previously, she covered agrifood policies as a staff reporter at Politico Europe from 2022 to 2023.
Read more »
Why the Giants Will Beat the Eagles, Why They Won’t, and a PredictionWhat is the Giants best path to an upset victory victory over the Eagles? Conversely, what factors could do them in?
Read more »
Find out why are trees losing leaves so quickly; why plants, lawns look stressedThere have been reports of trees suddenly dropping a lot of their leaves. While the windy weather earlier in the week helped some leaves fall off, some trees are dropping their leaves because it has been so dry.
Read more »
Why Hurricane Milton produced such strong tornadoes — and why future storms might do so againHurricane Milton brought an earlier-than-expected dose of chaos before it made landfall this week, as supercell thunderstorms — which feature rotating…
Read more »
Why the Batteries in Your Body’s Cells Only Come From Mom and Why It MattersWhen paternal mitochondria aren’t eliminated as they should be, it can lead to negative health consequences—and new research explains why.
Read more »