Why gene variant impairing alcohol breakdown raises heart disease risk

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Why gene variant impairing alcohol breakdown raises heart disease risk
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A gene variant that causes the 'alcohol flush' reaction increases the risk of heart disease by causing inflammation of blood vessels, especially in drinkers

variant, and derived endothelial cells from them – the type of cells that line blood vessels. They found that thecells had higher levels of free radicals and inflammation than normal endothelial cells, and were also less able to generate nitric oxide, which helps relax blood vessels. All these effects were exacerbated by exposing cells to alcohol.The gene variant also impairs the growth of new blood vessels.

The team found that an existing diabetes drug called empagliflozin may reduce these harmful effects in people withwho drink a lot of alcohol. But for Wu, the take-home message is clear. “If you’re missing this enzyme, try not to drink,” he says. “If you drink consistently, you are at much higher risk of heart disease, hypertension, diabetes and cancer.

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