A study explains why many cancer cells need the import of fat. The unexpected causes of cancer cells' frequent reliance on fat imports are being revealed by Columbia and MIT researchers. This discovery could help us better understand and control tumor development. The study, which was co-led by
The study, which was co-led by Matthew G. Vander Heiden, MD, Ph.D., director of the Koch Center atVagelos College of Physicians, was recently published in the journalThe oxygen we breathe and common nutrients like fat that we consume is likely to be crucial in the development of cancer cells.
Surprisingly, the new study discovered that hypoxic cancer cells often have more energy than they need for growth. Cancer cells did not react when the researchers added extra nutrients for energy production to the cells. “What makes our result very counterintuitive”, Vitkup says, “is that fat synthesis is not considered to be a process requiring a lot of oxygen. But our experiments demonstrated that up to 30% of oxygen used by cancer cells is not for energy generation but for synthesizing fats.”
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