When we interbred with Neanderthals, they were usually the fathers

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When we interbred with Neanderthals, they were usually the fathers
NeanderthalsHuman EvolutionAncient Humans
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Genetic evidence hints that there was a strong bias for male Neanderthals and female humans to mate, rather than any other combination

and male Neanderthals that mated. That’s the conclusion of a study of the genetic traces left in both populations by the intermixing. It isn’t clear why this sex-biased mating pattern would have happened.

It may be that male Neanderthals preferred femalefemales preferred Neanderthal males, or both. There is also no way to determine whether the matings were consensual or forced.at the University of Pennsylvania in Philadelphia. “The meaningful thing that we can say is that it was something that took place over generations.” Other geneticists say the evidence is intriguing but inconclusive. “I think we need more evidence, because it’s a big claim about the behaviour,” says– sometimes referred to as modern humans – and Neanderthals interbred after some members of our species moved out of Africa into Eurasia. There seem to have been multiple periods of interbreeding: one, and an earlier one that is harder to pin down, perhaps 200,000 years or more in the past. Today, all people of non-African descent carry some Neanderthal DNA.However, researchers haven’t paid much attention to how this affected the sex chromosomes. Females typically have two X chromosomes, while males usually have one X and one Y. Platt and his colleagues“One of the things that’s been pretty abundantly clear when looking at the human X chromosome is that it’s almost entirely a Neanderthal desert,” says Harris. Compared with other chromosomes, the human X chromosome is virtually devoid of Neanderthal DNA. The team considered four possible reasons for this.and Neanderthals were sufficiently different that their DNA didn’t work together very well. This is called hybrid incompatibility, and could cause human-Neanderthal hybrids to haveDNA than did the Neanderthal non-sex chromosomes – suggesting the X chromosome DNA from the two hominins was compatible., so natural selection would have struggled to eliminate harmful mutations. In contrast, modern humans had larger populations and bad mutations would have been cleared, so modern human X chromosome DNA would have spread in the Neanderthal population. However, the team says that doesn’t make sense either, because the modern human DNA retained on the Neanderthal X chromosome is mostly in non-functional regions, where it wouldn’t do any good. Alternatively, there could be a cultural reason. Societies differ in how the sexes move around: in some, females leave their home group to live with their sexual partners, but in others, it is the males who relocate. Modern human women moving to live with Neanderthals could produce a bias on the X chromosome, but it wouldn’t be enough to account for the strength of the bias the team found – even if every single interbreeding female was a modern human.preferred male Neanderthals over human partners – or both. “If they just like it that way, that explains everything,” says Platt. However, other geneticists say we cannot be so confident that the alternative explanations are wrong. Sümer points out that the earlier episode of interbreeding had a drastic effect on the Neanderthal genome: their original Y chromosomes were completely replacedat the Institute of Evolutionary Biology in Barcelona, Spain. The team assumed that it would be equally intense when Neanderthal DNA entered the modern human genome and vice versa. “That might not be the case,” he says. Coll Macià says we also need to consider yet another possibility: meiotic drive. Rogue genetic elements can cause one of a pair of chromosomes to be passed on more often than would be expected by chance. His team has found

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