What was SARS-CoV-2 antibody seroprevalence in Italian blood donors? CDC_NCEZID covid COVID19 SARSCoV2 blooddonors blood donors antibody seroprevalence
By Neha MathurJun 1 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Emerging Infectious Diseases Journal, researchers performed a prospective cohort study to evaluate titers and types of severe acute respiratory syndrome coronavirus 2 antibodies in voluntary blood donors in Modena, Italy, at different time points beginning from the start of coronavirus disease 2019 pandemic.
Background SARS-CoV-2 infection triggers neutralizing antibodies to various epitopes, including its nucleocapsid and spike protein receptor binding domain . However, titers of both natural and vaccine-induced SARS-CoV-2 antibodies vary with time. Related StoriesFinally, they used logistic regression to evaluate risk factors for symptomatic COVID-19.
Most VBDs were healthy; however, 68, 60, and 98 VBDs had rhinitis, obesity, and hypertension, respectively. Some VBDS were on angiotensin-converting enzyme [ACE] inhibitors, of which 9.1% of ACE users and 31% of non-ACE users had symptomatic COVID-19, with p values below 0.001, as assessed by χ2 test.
In 2022, all symptomatic cases had higher titers of antibodies against NC, regardless of vaccination. A consistent surge in titers of antibodies against all SARS-CoV-2 epitopes suggested elevation of viral circulation, and while vaccination reduced the clinical severity of COVID-19 but did not cease the increase in case numbers.
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