What is the efficacy of the COVID-19 second booster versus the first booster and prior COVID-19 infections? medrxivpreprint SantePubliqueFr COVID19 Coronavirus SARSCoV2 COVIDInfection Booster SecondBooster
By Bhavana KunkalikarJan 16 2023Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers assessed the efficacy of the coronavirus disease 2019 second booster vaccine compared to the first booster vaccine and the protection conferred by prior COVID-19 infection.
About the study In the present study, researchers utilized a test-negative design to determine the efficacy of the COVID-19 second booster vaccine compared to the first booster, along with the protection elicited by a prior COVID-19 diagnosis against Omicron BA.2 or BA.4/5 infection. Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The probabilities of testing SARS-CoV-2-positive with one or two booster vaccine doses, with or without prior infection, were compared between cases and controls using conditional logistic regression. The odds ratios were calculated based on the period since the last booster dosage, the prior infection, and the dominant SARS-CoV-2 variant when the prior infection was diagnosed.
Compared to participants vaccinated with the first booster dose approximately 181 to 210 days before testing, the relative protection observed seven to 30 days after the first booster was 64%, and after the second booster was 39%. For booster doses 1 and 2, a statistically significant reduction in relative vaccine effectiveness was found across periods since the last immunization.
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