This article from ACROBiosystems explores the associations between cytokines and autoimmune diseases.
Sponsored Content by ACROBiosystemsMay 3 2024Reviewed by Aimee Molineux Cytokine s, a class of protein signaling molecules synthesized by immune cells, are crucial in regulating immune responses and inflammation.
In addition to TNF-α, interleukin-6 and interleukin-1 also play a role in inflammation and joint degradation, prompting the use of their inhibitors, such as tocilizumab and canakinumab, respectively, for RA treatment. Notably, interleukin-17 and interleukin-23 also play important roles in this disease.
Heightened concentrations of IL-6 correlate with SLE activity and severity, prompting the use of tocilizumab, an anti-IL-6 receptor monoclonal antibody, for refractory cases. IL-1 involvement in SLE pathogenesis has led to trials of anakinra, an IL-1 inhibitor, for SLE treatment management. Interferon-gamma is a pro-inflammatory cytokine that is upregulated in patients with MS, leading to immune cell activation, which can encourage inflammation. Another important cytokine involved in the pathogenesis of MS is TNF-α.
Exploring the support ACROBiosystems offers in tackling autoimmune diseases Understanding and intervening in the roles of various cytokines in autoimmune diseases is key to understanding disease mechanisms and providing effective treatment strategies. Therapies targeting different cytokines have become an important strategy in treatment, offering hope and opportunities for improving patients' quality of life.
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