What impact does short-term sleep restriction have on gut microbiome? Microbiome Sleep Cortisol Inflammation gut microbiota SciReports wrair ORISEconnect USARIEM
The gut microbiota has been increasingly implicated as a mediator of adverse health effects related to disrupted/inadequate sleep. For example, sleep deprivation and fragmentation in rodents can change the gut microbial composition and cause inflammation, gut barrier damage, and intestinal permeability. However, the extent to which such effects occur in humans remains unclear.
About the study In the present study, researchers determined the effect of short-term, severe sleep deprivation on intestinal permeability and gut microbiota composition in adults. Inclusion criteria were healthy adults aged 17 – 45 with a body mass index lower than 30 kg/m2 and a regular sleep pattern of 7 – 9 hours per night, without using antibiotics in the past three months or a history of neurologic disorders, cardiometabolic, and gastrointestinal diseases.
DNA was extracted and quantified, and 16S rRNA sequencing was performed. Intestinal permeability was tested using a dual sugar absorption test after 72h of AS/SR. Subjects consumed a beverage comprising mannitol and lactulose dissolved in water, and urine produced in the next five hours was collected and assessed.
No participant consumed any beverage/food other than those provided. Serum cortisol levels declined from SR days 1 to 4 and remained lower on SR day 4 compared to AS day 4. The hsCRP concentrations were not different between SR days 1 and 4 or between SR and AS day 4. Urine volume was not different by sleep condition; mannitol or lactulose excretion and lactulose-to-mannitol ratio were not different between AS and SR.
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