A digital lifestyle program used in combination with semaglutide from low starting dose shows participants can maintain weight loss after tapering and stopping the drug, irrespective of starting BMI.
in patients who also follow a digital weight loss program can lead to maintenance of target weight up to 6 months later, show retrospective, real-world data.
"It's the same amount of weight loss seen in the phase 3 trials , so individuals also lose roughly 15% of the weight they have when they join our program but with a third of the medication. The lifestyle modifications actually work," Gudbergsen toldOf those patients who tapered off semaglutide to zero — data are available for 85 participants — a stable body weight was maintained for the first 26 weeks.
Gudbergsen also noted that the lower maximum dose facilitated engagement with supportive lifestyle changes throughout the program that"should help with losing weight and with keeping it off."Gudbergsen and his colleagues at Embla wanted to find out if semaglutide could be tailored to achieve weight loss with minimal side effects, as well as determining, whether once the target weight was achieved, the drug dose could be slowly tapered to zero without weight regain.
Participants received a tailored version of the standard semaglutide dosing schedule to ensure the lowest effective dose that accommodated any side effects. Doses were increased if weight loss stagnated, but if a weekly weight loss of at least 0.5% of body weight was achieved, then the dose remained the same. The tapering plan involved slowly reducing the medications over a median of 9 weeks.
A total of 240 patients stopped the drug completely, and available data from 85 of these participants showed an average body weight loss of −1.5% at 26 weeks after stopping. The median follow-up time after stopping was 19.5 weeks. Asked to comment on the work, Esben Selmer Buhl, MD, PhD, general practitioner physician, Institute for Health and Society, University of Oslo, Oslo, Norway, said,"We know from other studies that after a major weight loss — regardless of the regimen used — the weight adjusted metabolic rate is reduced by approximately 25%, and the patient's ability to feel satiety is vastly impaired while the feeling of hunger is vastly upregulated," he explained, adding that,"Studies also...
Weight Loss Obesity Obese Body Mass Index BMI Adverse Effects Side Effects Patient Safety Exercise Physical Activity Metabolism Metabolic
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