Researchers found that weak molecular interactions are essential for autophagy, a process where cells degrade unwanted components. This discovery could lead to new therapies for neurodegenerative diseases and cancer.
Cells degrade components that are no longer needed through autophagy. New results show that a weak molecular interaction is essential for this process. By modifying this interaction, it is possible to artificially trigger autophagy, which could then enable the degradation of deposits in neurodegenerative diseases such as Alzheimer's, or support cancer therapies.
Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks. This vital process prevents the formation of harmful aggregates and makes nutrients available again. A research team co-led by Prof. Dr. Claudine Kraft from the CIBSS Cluster of Excellence at the University of Freiburg and Dr. Florian Wilfling from the Max Planck Institute of Biophysics in Frankfurt has now discovered the conditions necessary for autophagy to start. They were also able to artificially create these conditions and thus trigger the degradation of otherwise non-degradable molecules in yeast cells. Targeting autophagy in this way is a promising approach for promoting the degradation of aggregates that can otherwise form plaques in neurodegenerative diseases such as Alzheimer's, as well as to improve the efficacy of cancer treatments. The study has been published in the scientific journalIn order for the degradation of cellular components through autophagy to occur, they must first be recognised as waste. This is done by receptor and other adapter molecules. However, it was previously unknown how exactly these molecules trigger the subsequent steps.'We have now been able to show that the receptors must bind weakly to the material to be disposed of for autophagy to start,' explains Kraft.'If they bind too strongly, the process is not triggere
Autophagy Molecular Interaction Disease Cancer Neurodegenerative Diseases
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