Malcolm O’Malley and his mom sat nervously in the doctor’s office awaiting the results of his bloodwork. This was no ordinary check-up. In fact, this
appointment was more urgent and important than the SATs the seventeen-year-old, college hopeful had spent months preparing for and was now missing in order to understand his symptoms.
“Anaphylaxis is super deadly and the only treatment for it is epinephrine; and I remember thinking, ‘how is this the best we have?’ because epinephrine does not actually treat the immune system at all – it’s just adrenaline,” said O’Malley, who recently returned to his studies as a Ph.D. student of Biomedical Engineering at the University of Virginia in Charlottesville.
jsc2022e083018 — A preflight image of beating cardiac spheroid composed of iPSC-derived cardiomyocytes , endothelial cells , and cardiac fibroblasts . These cells are incubated and put under the microscope in space as part of the Effect of Microgravity on Drug Responses Using Heart Organoids investigation.“The immune system is involved in everything,” O’Malley says.
“It’s exciting that we just never know what’s going to happen, how the immune system is going to react until it’s already been activated or challenged in some way,” said O’Malley. “I’m particularly interested in the adaptive immune system because it’s always evolving to meet new challenges; whether it’s a pandemic-level virus, bacteria or something on a mission to Mars, our bodies are going to have some kind of adaptive immune response.
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