Allergy medications like antihistamines can provide relief during autumn, but a new study suggests they may be lethal to victims of the opioid epidemic.
Sedating antihistamines, like diphenhydramine, can exacerbate opioid-induced respiratory depression, which is characterized by decreased breathing and the most common cause of death during an overdose, Martins said.
“Because antihistamines do not respond to naloxone, co-involved opioid and antihistamine overdoses might require naloxone administration plus other immediate medical response measures to prevent death,” said lead author Amanda T. Dinwiddie, a health scientist at the National Center for Injury Prevention and Control’s division of overdose prevention.
"Some might have tried to self-medicate side effects and inadvertently got more sedated,” Martins said.
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