Caleb Daniels added 14 points for the Wildcats (30-7), and fifth-year senior Collin Gillespie's only made field goal was a clutch shot late.
With both teams willing to limit possessions, the first spot for this year's Final Four in New Orleans was settled in a game that was ugly to watch with all the missed shots.
The Wildcats and coach Jay Wright won't complain as he seeks to add a third national title to the ones he won in 2016 and 2018. Villanova will play either Kansas, the only No. 1 seed remaining, or 10th-seeded Miami in the Final Four next Saturday in New Orleans as it seeks its fourth championship overall.
After Villanova missed three shots on the same possession — and was still without any second-chance points in the game — Moore got the long rebound on the break. After initially slowing things down, Moore scored on a drive against Gillespie, getting Houston within 42-40 with 5:25 left. Gillespie, who played in the national championship game for the Wildcats in 2018, was 1-of-6 shooting. But his only field goal came on the possession after the timeout when he stepped inside the 3-point line and hit a jumper with 5:02 left.
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