Science, Space and Technology News 2024
Transmission electron micrograph of HIV-1 virus particles replicating from the plasma membrane of an H9 T cell . Image captured at the NIAID Integrated Research Facility in Fort Detrick, Maryland. Credit: NIAID
A weekly injection of semaglutide was safe and reduced the amount of fat in the liver by 31% in people with HIV and metabolic dysfunction-associated steatotic liver disease , according to a presentation today at the 2024 Conference on Retroviruses and Opportunistic Infections in Denver. It is the most common cause of chronic liver disease in the United States, and a leading reason for liver transplantation. An estimated 30-40% of people with HIV experience MASLD, slightly higher than the average among people without HIV. Semaglutide is an antidiabetic medication approved for use in the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management.
Participants experienced an average 31% reduction in liver fat, with 29% of participants experiencing a complete resolution of MASLD, meaning their liver fat decreased to 5% or less of overall liver content. They also experienced weight loss, reduced fasting blood glucose , and reduced fasting triglycerides , consistent with effects observed in studies of semaglutide in people without HIV.
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