Genetics can predict the toxicity of cancer immunotherapy, via a mechanism shared with autoimmune diseases. In their News and Views, Caroline Robert & colleagues discuss the implications for biomarker and treatment strategies. GustaveRoussy Inserm
gene predicts the toxicity of checkpoint inhibitors in patients with cancer, via a mechanism shared with autoimmune diseases — which could inform biomarker and treatment strategies in both of these contexts.
Immune-checkpoint inhibitors are increasingly used to treat a variety of cancers and are highly effective in many patients; however, because they reactivate a patient’s immune system, they can also lead to a variety of potentially severe immune-related adverse events . These irAEs can resemble autoimmune diseases such as Crohn’s disease-like ulcerative colitis, rheumatoid arthritis, type 1 diabetes and vitiligoid skin depigmentation.
United States Latest News, United States Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Reporting the early stage clinical evaluation of virtual-reality-based intervention trials: RATE-VR - Nature MedicineReporting the early stage clinical evaluation of virtual-reality-based intervention trials: RATE-VR. Correspondence from Michel E. van Genderen and colleagues.
Read more »
Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag - Nature BiotechnologyThree epigenetic features are mapped at single-cell resolution using Tn5-nanobody fusion proteins
Read more »
Smart thermometers are tracking data on your fevers — and it’s helping stores keep medicine shelves stockedKinsa's smart thermometer provides data on where illness is spreading. This winter is expected to be the worst for non-COVID illness in three years. The company's data can be used to tell retailers and brands where medicine will be in high demand.
Read more »
Children’s fever medicine is in short supply, but parents have optionsWhile there’s no problem in manufacturing the drugs, sold as Tylenol and Motrin, above-average demand has led to empty store shelves in some places. King Soopers has limited customers to buyi…
Read more »
China, Canada confident of securing 'peace pact for nature' at COP15Talks are set to wrap up on Monday in Montreal and countries are racing to agree on language in framework that calls for protecting 30% of global land and marine areas by 2030 and providing tens of billions of dollars to developing countries.
Read more »
Mourning 'L.A.’s coolest cat' and celebrating how P-22 changed our relationship with natureAfter P-22's death Saturday, a congressman called him a “beloved mascot' and a biologist described him as an “iconic ambassador for wildlife.”
Read more »