Dr Mark Kris discusses clinical trial findings supporting the use of olanzapine for patients receiving chemotherapy.
Professor, Department of Medicine, Weill Cornell Medical College; Attending Physician, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York , NYServe as a director, officer, partner, employee, advisor, consultant, or trustee for: AstraZeneca; Roche/Genentech; Ariad Pharmaceuticals
They use a standard therapy, and if you go to the NCCN guidelines, this is a highly emetogenic drug, and patients should get a 5-HT3 antagonist, an NK-1 antagonist, and. If you go to the preferred antiemetic regimen for highly emetogenic therapy, like carboplatin over AUC4, you should be getting olanzapine. In this trial, they randomized 5 mg olanzapine daily for 4 days vs placebo.
This is a very important paper. Adding in a drug that costs pennies that's already a standard therapy — actually, if you're following the preferred regimen for emetogenic chemotherapy via the NCCN guidelines, you should be giving olanzapine. Not a single patient had a side effect that caused the therapies to be discontinued. To me, this is a very important paper. It deals with a cancer regimen that is a standard of care worldwide. It's a standard of care for everybody with lung cancer, regardless of cell type and regardless of molecular characteristics.
CINV Social Determinants Of Health SDOH Social Determinants Of Health (SDOH) Toxicology Toxicity Poisoning Toxins Anxiety Quality Of Life QOL Health Related Quality Of Life Health-Related Quality Of Life HRQOL Nausea Lung Cancer Lung Carcinoma Cancer Of The Lung Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Chemotherapy New York
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