USC vs Michigan Early Picks, Predictions & Odds for Week 4

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USC vs Michigan Early Picks, Predictions & Odds for Week 4
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Get the latest USC vs Michigan predictions ahead of their Saturday showdown. Free early college football picks and predictions for September 21.

A Top 25 showdown sees USC travel to Michigan to take on a Wolverines side starting a new quarterback. Will a change under center be enough to kick start the Maize and Blue's offense? Our early predictions believe so.There’s a new starting QB at Michigan, and he’ll be thrown into the fire with his first start against a USC team that’s in the thick of the College Football Playoff conversation.

The Tigers nearly lost to South Carolina in Week 3 and probably would have if not for multiple controversial calls. LSU’s defense is just 68th in SP+ and Michigan is a whole other animal. It’s also safe to assume with Alex Orji named the new starter, the Wolverines will lean heavily on their run game. Orji’s a dynamic athlete who was on Bruce Feldman’s Freaks List for good reason.

With an expanded run game and a dominant defense, Michigan will keep this close in a losing effort. Although, SP+ is projecting a 30-26 win for the Wolverines.In a battle of two teams that were among the worst P4 defenses while having top-tier offenses last year, USC beat LSU 27-20 in Week 1 this year.

Even an iffy USC defense should be able to contain the Wolverines and keep them from scoring more than 20 points. They’re averaging just 23.3 this season, and that’s after playing two G5 programs, along with Texas. I don’t expect this total to see much movement, but I wouldn’t bet the Under if it dips to below 45.5. : Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.

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