The American Academy of Pediatrics recommended use of weight-loss drugs in children ages 12 years or older for treatment of obesity, which impacts about 14.4 million kids and adolescents in the United States and can lead to serious health complications.
The new guidelines - the first in over a decade - focus on treatment of obesity, as opposed to prevention.
Metformin has been used off label to achieve weight loss in children. Of the 27 randomized trials of metformin for weight loss in children reviewed by the guidelines panel, 74% showed some positive effect of the medication. GlaxoSmithKline's orlistat is approved by the US Food and Drug Administration for long-term treatment of obesity in children age 12 and older. The appetite suppressant phentermine is approved for ages 16 and older.
The guidelines panel noted that many of the trials it reviewed excluded children with mental health conditions, physical activity limitations, or use of certain medications.
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