Prostate cancer screening tests lack specificity in detecting higher-grade tumors, but a new urine test could help detect aggressive cancers.
To date, men undergoing screening through the measurement of prostate-specific antigen levels have had a significant reduction in neoplastic mortality. Because of its low specificity, however, this practice often leads to frequent, unnecessary, invasive biopsies and the diagnosis of low-grade, indolent cancer. While guided biopsies with multiparametric MRI can improve the diagnosis of grade 2 prostate cancer s, widespread implementation remains challenging.
Thus, a urine test called MyProstateScore 2.0 was developed, with two formulations: MPSA2 and MPSA2+, depending on whether a prostate volume was considered. The final MPSA2 development model included clinical data and 17 of the most informative markers, including nine specific to cancer, which were associated with theThe external validation cohort consisted of participants in the NCI EDRN PCA3 Evaluation trial.
Among patients who have had a negative first biopsy, MPS2 would have a sensitivity of 94.4% and a specificity of 51%, which is much higher than other tests like prostate cancer antigen 3 gene, three-gene model, and MPS. In addition, in patients with grade 1 prostate cancer, urinary markers for high-grade cancer could indicate the existence of a more aggressive tumor requiring increased monitoring.
Malignant Prostate Neoplasm Prostate Cancer Cancer Of The Prostate Metastatic And Advanced Prostate Cancer Surveillance Of Prostate Cancer Cancer Malignant Neoplasia Carcinoma Malignant Neoplasm Prostatic Biologic Therapy Biologics Prostate Specific Antigen PSA- Prostate Specific Antigen Genomics Genomic Medicine Biopsy Biomarker Biological Marker
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